Item Type | Name |
Concept
|
Adjuvants, Immunologic
|
Concept
|
Growth Inhibitors
|
Concept
|
Enzyme Inhibitors
|
Concept
|
Immunologic Surveillance
|
Concept
|
Dose-Response Relationship, Drug
|
Concept
|
Immune Tolerance
|
Concept
|
Immunologic Capping
|
Concept
|
Immune System Diseases
|
Concept
|
Immunotherapy
|
Concept
|
Enzyme-Linked Immunosorbent Assay
|
Concept
|
Immunohistochemistry
|
Concept
|
Protease Inhibitors
|
Concept
|
Immunoenzyme Techniques
|
Concept
|
Receptors, Immunologic
|
Concept
|
Angiogenesis Inhibitors
|
Concept
|
Immunoconjugates
|
Concept
|
Topoisomerase I Inhibitors
|
Concept
|
Chromatin Immunoprecipitation
|
Concept
|
Cyclin-Dependent Kinase Inhibitor p21
|
Concept
|
Structure-Activity Relationship
|
Concept
|
Immunoprecipitation
|
Concept
|
Immunoblotting
|
Concept
|
Topoisomerase Inhibitors
|
Concept
|
Inhibitory Concentration 50
|
Concept
|
Cell Cycle Checkpoints
|
Concept
|
G1 Phase Cell Cycle Checkpoints
|
Concept
|
Immune Evasion
|
Concept
|
Cyclin-Dependent Kinase Inhibitor p27
|
Concept
|
Immunity
|
Concept
|
Protein Kinase Inhibitors
|
Academic Article
|
The related adhesion focal tyrosine kinase forms a complex with paxillin in hematopoietic cells.
|
Academic Article
|
Growth inhibition and modulation of kinase pathways of small cell lung cancer cell lines by the novel tyrosine kinase inhibitor STI 571.
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Academic Article
|
Expression of the focal adhesion protein paxillin in lung cancer and its relation to cell motility.
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Academic Article
|
Gemcitabine and vinorelbine in patients with advanced lung cancer: preclinical studies and report of a phase I trial.
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Academic Article
|
A cdc15-like adaptor protein (CD2BP1) interacts with the CD2 cytoplasmic domain and regulates CD2-triggered adhesion.
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Academic Article
|
ATP6S1 elicits potent humoral responses associated with immune-mediated tumor destruction.
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Academic Article
|
BAL is a novel risk-related gene in diffuse large B-cell lymphomas that enhances cellular migration.
|
Academic Article
|
Regulation of cellular proliferation, cytoskeletal function, and signal transduction through CXCR4 and c-Kit in small cell lung cancer cells.
|
Academic Article
|
CD2 molecules redistribute to the uropod during T cell scanning: implications for cellular activation and immune surveillance.
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Academic Article
|
Vaccination with irradiated autologous tumor cells engineered to secrete granulocyte-macrophage colony-stimulating factor augments antitumor immunity in some patients with metastatic non-small-cell lung carcinoma.
|
Academic Article
|
Modulation of the c-Met/hepatocyte growth factor pathway in small cell lung cancer.
|
Academic Article
|
Role of receptor tyrosine kinases in lung cancer.
|
Academic Article
|
Activated c-Met signals through PI3K with dramatic effects on cytoskeletal functions in small cell lung cancer.
|
Academic Article
|
Flow cytometric determination of lipid peroxidation using fluoresceinated phosphoethanolamine.
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Academic Article
|
Use of cytokeratins 7 and 20 in determining the origin of metastatic carcinoma of unknown primary, with special emphasis on lung cancer.
|
Academic Article
|
Targeted molecules in small cell lung cancer.
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Academic Article
|
Small-cell cancers, and an unusual reaction to chemotherapy. Case 1. Extrapulmonary small-cell carcinoma arising in the prostate.
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Academic Article
|
Targeting c-Kit mutations: basic science to novel therapies.
|
Academic Article
|
Reliable and sensitive identification of occult tumor cells using the improved rare event imaging system.
|
Academic Article
|
Phase II study of imatinib in patients with small cell lung cancer.
|
Academic Article
|
Therapeutic targeting of the receptor tyrosine kinase Met.
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Academic Article
|
A selective small molecule c-MET Inhibitor, PHA665752, cooperates with rapamycin.
|
Academic Article
|
Modulation of c-Kit/SCF pathway leads to alterations in topoisomerase-I activity in small cell lung cancer.
|
Academic Article
|
c-Met as a target for human cancer and characterization of inhibitors for therapeutic intervention.
|
Academic Article
|
Novel therapies in lung cancer.
|
Academic Article
|
Expression of Siva-1 protein or its putative amphipathic helical region enhances cisplatin-induced apoptosis in breast cancer cells: effect of elevated levels of BCL-2.
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Academic Article
|
A selective small molecule inhibitor of c-Met, PHA665752, inhibits tumorigenicity and angiogenesis in mouse lung cancer xenografts.
|
Academic Article
|
Epidermal growth factor receptor mutations and susceptibility to targeted therapy in lung cancer.
|
Academic Article
|
c-Met inhibition.
|
Academic Article
|
A review of topoisomerase inhibition in lung cancer.
|
Academic Article
|
Efficacy and safety of bevacizumab plus erlotinib for patients with recurrent ovarian, primary peritoneal, and fallopian tube cancer: a trial of the Chicago, PMH, and California Phase II Consortia.
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Academic Article
|
Vitamin D receptor expression in normal, premalignant, and malignant human lung tissue.
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Academic Article
|
PAX5 is expressed in small-cell lung cancer and positively regulates c-Met transcription.
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Academic Article
|
Phase I trial of erlotinib-based multimodality therapy for inoperable stage III non-small cell lung cancer.
|
Academic Article
|
Protein kinase C beta in malignant pleural mesothelioma.
|
Academic Article
|
EGFR-targeted therapeutics: focus on SCCHN and NSCLC.
|
Academic Article
|
The MET receptor tyrosine kinase is a potential novel therapeutic target for head and neck squamous cell carcinoma.
|
Academic Article
|
Receptor tyrosine kinases and inhibitors in lung cancer.
|
Academic Article
|
Concerted potent humoral immune responses to autoantigens are associated with tumor destruction and favorable clinical outcomes without autoimmunity.
|
Academic Article
|
Role of c-Met in cancer: emphasis on lung cancer.
|
Academic Article
|
EphA2 mutation in lung squamous cell carcinoma promotes increased cell survival, cell invasion, focal adhesions, and mammalian target of rapamycin activation.
|
Academic Article
|
Ethnic differences and functional analysis of MET mutations in lung cancer.
|
Academic Article
|
Fyn: a novel molecular target in cancer.
|
Academic Article
|
Methylnaltrexone potentiates the anti-angiogenic effects of mTOR inhibitors.
|
Academic Article
|
CBL is frequently altered in lung cancers: its relationship to mutations in MET and EGFR tyrosine kinases.
|
Academic Article
|
Rapid and dramatic radiographic and clinical response to an ALK inhibitor (crizotinib, PF02341066) in an ALK translocation-positive patient with non-small cell lung cancer.
|
Academic Article
|
Preclinical studies of the proteasome inhibitor bortezomib in malignant pleural mesothelioma.
|
Academic Article
|
Non-receptor tyrosine kinase inhibitors in lung cancer.
|
Academic Article
|
FYN is overexpressed in human prostate cancer.
|
Academic Article
|
Effect of a c-Met-specific, ATP-competitive small-molecule inhibitor SU11274 on human ovarian carcinoma cell growth, motility, and invasion.
|
Academic Article
|
Autotaxin induces lung epithelial cell migration through lysoPLD activity-dependent and -independent pathways.
|
Academic Article
|
Differential expression of RON in small and non-small cell lung cancers.
|
Academic Article
|
Activity of XL184 (Cabozantinib), an oral tyrosine kinase inhibitor, in patients with medullary thyroid cancer.
|
Academic Article
|
Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer.
|
Academic Article
|
CD14(+)S100A9(+) myeloid-derived suppressor cells portend decreased survival in patients with advanced lung cancer.
|
Academic Article
|
Control of bleeding in patients with immune and nonimmune thrombocytopenia with aminocaproic acid.
|
Academic Article
|
MET amplification identifies a small and aggressive subgroup of esophagogastric adenocarcinoma with evidence of responsiveness to crizotinib.
|
Academic Article
|
Sphingosine kinase 1 is required for mesothelioma cell proliferation: role of histone acetylation.
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Academic Article
|
c-Met is a potentially new therapeutic target for treatment of human melanoma.
|
Academic Article
|
Shc phosphorylation in myeloid cells is regulated by granulocyte macrophage colony-stimulating factor, interleukin-3, and steel factor and is constitutively increased by p210BCR/ABL.
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Academic Article
|
The thrombopoietin receptor c-MPL activates JAK2 and TYK2 tyrosine kinases.
|
Academic Article
|
Novel functional germline variants in the VEGF receptor 2 gene and their effect on gene expression and microvessel density in lung cancer.
|
Academic Article
|
Prognostic significance of angiogenesis and angiogenic growth factors in nonsmall cell lung cancer.
|
Academic Article
|
Effect of crizotinib on overall survival in patients with advanced non-small-cell lung cancer harbouring ALK gene rearrangement: a retrospective analysis.
|
Academic Article
|
Phase II study of the multitargeted tyrosine kinase inhibitor XL647 in patients with non-small-cell lung cancer.
|
Academic Article
|
Activity and safety of crizotinib in patients with ALK-positive non-small-cell lung cancer: updated results from a phase 1 study.
|
Academic Article
|
A novel small molecule met inhibitor induces apoptosis in cells transformed by the oncogenic TPR-MET tyrosine kinase.
|
Academic Article
|
Mechanisms of metastasis as related to receptor tyrosine kinases in small-cell lung cancer.
|
Academic Article
|
Haptoglobin alpha-subunit and hepatocyte growth factor can potentially serve as serum tumor biomarkers in small cell lung cancer.
|
Academic Article
|
A phase I study of pemetrexed, carboplatin, and concurrent radiotherapy in patients with locally advanced or metastatic non-small cell lung or esophageal cancer.
|
Academic Article
|
Disruption of the EGFR E884-R958 ion pair conserved in the human kinome differentially alters signaling and inhibitor sensitivity.
|
Academic Article
|
Novel targets for therapeutic agents in small cell lung cancer.
|
Academic Article
|
The role of EGFR inhibition in the treatment of non-small cell lung cancer.
|
Academic Article
|
Expression patterns of PAX5, c-Met, and paxillin in neuroendocrine tumors of the lung.
|
Academic Article
|
RON (MST1R) is a novel prognostic marker and therapeutic target for gastroesophageal adenocarcinoma.
|
Academic Article
|
Activity of crizotinib (PF02341066), a dual mesenchymal-epithelial transition (MET) and anaplastic lymphoma kinase (ALK) inhibitor, in a non-small cell lung cancer patient with de novo MET amplification.
|
Academic Article
|
Degradation and regurgitation of extracellular proteins by cultured mouse peritoneal macrophages and baby hamster kidney fibroblasts. Kinetic evidence that the transfer of proteins to lysosomes is not irreversible.
|
Academic Article
|
Critical role for the receptor tyrosine kinase EPHB4 in esophageal cancers.
|
Academic Article
|
The EphB4 receptor tyrosine kinase promotes lung cancer growth: a potential novel therapeutic target.
|
Academic Article
|
EphB4 as a therapeutic target in mesothelioma.
|
Academic Article
|
TLR3 agonists and proinflammatory antitumor activities.
|
Academic Article
|
MET and PI3K/mTOR as a potential combinatorial therapeutic target in malignant pleural mesothelioma.
|
Academic Article
|
Crizotinib in ROS1-rearranged non-small-cell lung cancer.
|
Academic Article
|
Non-small cell lung cancer is susceptible to induction of DNA damage responses and inhibition of angiogenesis by telomere overhang oligonucleotides.
|
Academic Article
|
Multiple Endocrine Disruption by the MET/ALK Inhibitor Crizotinib in Patients With Non-small Cell Lung Cancer.
|
Academic Article
|
Combined MET inhibition and topoisomerase I inhibition block cell growth of small cell lung cancer.
|
Academic Article
|
Dramatic antitumor effects of the dual MET/RON small-molecule inhibitor LY2801653 in non-small cell lung cancer.
|
Academic Article
|
Dose-finding and pharmacokinetic study to optimize the dosing of irinotecan according to the UGT1A1 genotype of patients with cancer.
|
Academic Article
|
Targeting myeloid-derived suppressor cells augments antitumor activity against lung cancer.
|
Academic Article
|
A new hope for precision medicine.
|
Academic Article
|
A safety assessment of crizotinib in the treatment of ALK-positive NSCLC patients.
|
Academic Article
|
A multicenter phase I study of pazopanib in combination with paclitaxel in first-line treatment of patients with advanced solid tumors.
|
Academic Article
|
Molecularly targeted therapies in non-small-cell lung cancer annual update 2014.
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Academic Article
|
A randomized phase II study of ganetespib, a heat shock protein 90 inhibitor, in combination with docetaxel in second-line therapy of advanced non-small cell lung cancer (GALAXY-1).
|
Academic Article
|
Engineering Synthetic Antibody Inhibitors Specific for LD2 or LD4 Motifs of Paxillin.
|
Academic Article
|
Activation of MET via diverse exon 14 splicing alterations occurs in multiple tumor types and confers clinical sensitivity to MET inhibitors.
|
Academic Article
|
Phase II Study of the AKT Inhibitor MK-2206 plus Erlotinib in Patients with Advanced Non-Small Cell Lung Cancer Who Previously Progressed on Erlotinib.
|
Academic Article
|
Randomized Phase Ib/II Study of Gemcitabine Plus Placebo or Vismodegib, a Hedgehog Pathway Inhibitor, in Patients With Metastatic Pancreatic Cancer.
|
Academic Article
|
Selumetinib with and without erlotinib in KRAS mutant and KRAS wild-type advanced nonsmall-cell lung cancer.
|
Academic Article
|
Effective growth-suppressive activity of maternal embryonic leucine-zipper kinase (MELK) inhibitor against small cell lung cancer.
|
Academic Article
|
Comprehensive Genomic Profiling Identifies a Subset of Crizotinib-Responsive ALK-Rearranged Non-Small Cell Lung Cancer Not Detected by Fluorescence In Situ Hybridization.
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Academic Article
|
FAK and paxillin, two potential targets in pancreatic cancer.
|
Academic Article
|
Met gene amplification and protein hyperactivation is a mechanism of resistance to both first and third generation EGFR inhibitors in lung cancer treatment.
|
Academic Article
|
Targeting the HER Family with Pan-HER Effectively Overcomes Resistance to Cetuximab.
|
Academic Article
|
PI3 Kinase Pathway and MET Inhibition is Efficacious in Malignant Pleural Mesothelioma.
|
Academic Article
|
Crizotinib (PF02341066) as a ALK /MET inhibitor- Special Emphasis as a Therapeutic Drug Against Lung Cancer.
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Academic Article
|
Activity and safety of brigatinib in ALK-rearranged non-small-cell lung cancer and other malignancies: a single-arm, open-label, phase 1/2 trial.
|
Academic Article
|
RETRACTED: The receptor tyrosine kinase AXL mediates nuclear translocation of the epidermal growth factor receptor.
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Academic Article
|
TOPK (T-LAK cell-originated protein kinase) inhibitor exhibits growth suppressive effect on small cell lung cancer.
|
Academic Article
|
Expression and mutational analysis of c-CBL and its relationship to the MET receptor in head and neck squamous cell carcinoma.
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Academic Article
|
A phase I study of XL184, a RET, VEGFR2, and MET kinase inhibitor, in patients (pts) with advanced malignancies, including pts with medullary thyroid cancer (MTC).
|
Academic Article
|
Refining epidermal growth factor receptor (EGFR) -inhibition-related rash (EIRR) phenotypes with a cetuximab (C) monotherapy stage of a phase II trial for non-small cell lung cancer (NSCLC).
|
Academic Article
|
MET in Lung Cancer: Biomarker Selection Based on Scientific Rationale.
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Academic Article
|
Camptothecin resistance is determined by the regulation of topoisomerase I degradation mediated by ubiquitin proteasome pathway.
|
Academic Article
|
Complete Pathologic Response When Adding Pembrolizumab to Neoadjuvant Chemotherapy in Stage IIIA Non-Small-Cell Lung Cancer.
|
Academic Article
|
Effective osimertinib treatment in a patient with discordant T790 M mutation detection between liquid biopsy and tissue biopsy.
|
Academic Article
|
Differential responsiveness of MET inhibition in non-small-cell lung cancer with altered CBL.
|
Academic Article
|
Development of PD-1 and PD-L1 inhibitors as a form of cancer immunotherapy: a comprehensive review of registration trials and future considerations.
|
Academic Article
|
Responses to Alectinib in ALK-rearranged Papillary Renal Cell Carcinoma.
|
Academic Article
|
A phase I open-label dose-escalation study of the anti-HER3 monoclonal antibody LJM716 in patients with advanced squamous cell carcinoma of the esophagus or head and neck and HER2-overexpressing breast or gastric cancer.
|
Academic Article
|
Combination systemic therapies with immune checkpoint inhibitors in pancreatic cancer: overcoming resistance to single-agent checkpoint blockade.
|
Academic Article
|
The gut microbiome and response to immune checkpoint inhibitors: preclinical and clinical strategies.
|
Academic Article
|
Combined Checkpoint Inhibition and Chemotherapy: New Era of 1st-Line Treatment for Non-Small-Cell Lung Cancer.
|
Academic Article
|
Phenotypic Switching of Naïve T Cells to Immune-Suppressive Treg-Like Cells by Mutant KRAS.
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Academic Article
|
Dose-escalation trial of the ALK, MET & ROS1 inhibitor, crizotinib, in patients with advanced cancer.
|
Academic Article
|
Presence and structure-activity relationship of intrinsically disordered regions across mucins.
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Academic Article
|
Effects of selected deubiquitinating enzyme inhibitors on the proliferation and motility of lung cancer and mesothelioma cell lines.
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Academic Article
|
The promise of selective MET inhibitors in non-small cell lung cancer with MET exon 14 skipping.
|
Academic Article
|
Targeting FTO Suppresses Cancer Stem Cell Maintenance and Immune Evasion.
|
Academic Article
|
Association of molecular characteristics with survival in advanced non-small cell lung cancer patients treated with checkpoint inhibitors.
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Academic Article
|
MET receptor in oncology: From biomarker to therapeutic target.
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Academic Article
|
Evaluation of Omics-Based Strategies for the Management of Advanced Lung Cancer.
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Academic Article
|
Epigenetic landscape of small cell lung cancer: small image of a giant recalcitrant disease.
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Academic Article
|
Hyperprogression on immunotherapy with complete response to chemotherapy in a NSCLC patient with high PD-L1 and STK11: A case report.
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Academic Article
|
Role of immunotherapy and co-mutations on KRAS-mutant non-small cell lung cancer survival.
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Academic Article
|
Rapid progression of disease from immunotherapy following targeted therapy: insights into treatment management and sequence.
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Academic Article
|
Prolonged survival and response to tepotinib in a non-small-cell lung cancer patient with brain metastases harboring MET exon 14 mutation: a research report.
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Academic Article
|
Salmonella-Based Therapy Targeting Indoleamine 2,3-Dioxygenase Restructures the Immune Contexture to Improve Checkpoint Blockade Efficacy.
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Academic Article
|
Inhibitors of the Transcription Factor STAT3 Decrease Growth and Induce Immune Response Genes in Models of Malignant Pleural Mesothelioma (MPM).
|
Academic Article
|
Co-stimulatory and co-inhibitory immune markers in solid tumors with MET alterations.
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Academic Article
|
Multicohort Retrospective Validation of a Predictive Biomarker for Topoisomerase I Inhibitors.
|
Academic Article
|
Molecular and Clinical Features of Hospital Admissions in Patients with Thoracic Malignancies on Immune Checkpoint Inhibitors.
|
Academic Article
|
Immunotherapy in Non-Small Cell Lung Cancer Patients with Brain Metastases: Clinical Challenges and Future Directions.
|
Academic Article
|
Immune Checkpoint Inhibitor-Induced Myocarditis with Myositis/Myasthenia Gravis Overlap Syndrome: A Systematic Review of Cases.
|
Academic Article
|
JNJ-64041757 (JNJ-757), a Live, Attenuated, Double-Deleted Listeria monocytogenes-Based Immunotherapy in Patients With NSCLC: Results From Two Phase 1 Studies.
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Academic Article
|
Infectious complications of immune checkpoint inhibitors in solid organ malignancies.
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Academic Article
|
Patterns of Care in Maintenance Therapy in US Patients Undergoing Definitive Chemoradiation for Stage 3 Non-Small Cell Lung Cancer (NSCLC).
|
Academic Article
|
Novel Therapeutic Targets and Immune Dysfunction in Malignant Pleural Mesothelioma.
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Academic Article
|
Exploring the Next Frontier in Non-Small-Cell Lung Cancer With High MET and Mutated Epidermal Growth Factor Receptor.
|
Academic Article
|
Clinical and Molecular Features of KRAS-Mutated Lung Cancer Patients Treated with Immune Checkpoint Inhibitors.
|
Academic Article
|
Precision oncology provides opportunities for targeting KRAS-inhibitor resistance.
|
Academic Article
|
Predicting survival of NSCLC patients treated with immune checkpoint inhibitors: Impact and timing of immune-related adverse events and prior tyrosine kinase inhibitor therapy.
|
Academic Article
|
Management of infusion-related reactions (IRRs) in patients receiving amivantamab in the CHRYSALIS study.
|
Academic Article
|
A Closer Look at EGFR Inhibitor Resistance in Non-Small Cell Lung Cancer through the Lens of Precision Medicine.
|
Concept
|
Antineoplastic Agents, Immunological
|
Concept
|
Inhibitor of Growth Protein 1
|
Concept
|
Proteasome Inhibitors
|
Concept
|
Drug-Related Side Effects and Adverse Reactions
|
Grant
|
Role of Paxillin in Lung Cancer
|
Grant
|
MINIMAL RESIDUAL TUMOR IN SMALL CELL LUNG CANCER
|
Grant
|
Role of c-Met in SCLC and Potential for Novel Therapy
|
Grant
|
Novel Targeted Therapy in Pancreatic Cancer
|
Grant
|
Studies of a Novel Therapeutic Target in Non-Small Cell Lung Cancer (NSCLC)
|
Grant
|
PAXILLIN--AN ONCOGENE ACTIVATED PROTEIN
|
Academic Article
|
Twelve-Month Follow-up of the Immune Response After COVID-19 Vaccination in Patients with Genitourinary Cancers: A Prospective Cohort Analysis.
|
Academic Article
|
Complete response to chemoimmunotherapy with bevacizumab in synchronous multiple primary cancers: pulmonary adenocarcinoma and sarcomatoid carcinoma.
|
Academic Article
|
Dual Axl/MerTK inhibitor INCB081776 creates a proinflammatory tumor immune microenvironment and enhances anti-PDL1 efficacy in head and neck cancer.
|
Academic Article
|
LSD1-targeted therapy-a multi-purpose key to unlock immunotherapy in small cell lung cancer.
|
Academic Article
|
Selpercatinib and Pralsetinib Induced Chylous Ascites in RET-Rearranged Lung Adenocarcinoma: A Case Series.
|
Academic Article
|
Targeting ITGB4/SOX2-driven lung cancer stem cells using proteasome inhibitors.
|
Academic Article
|
Acquired resistance to KRAS G12C small-molecule inhibitors via genetic/nongenetic mechanisms in lung cancer.
|
Academic Article
|
A Nexus between Genetic and Non-Genetic Mechanisms Guides KRAS Inhibitor Resistance in Lung Cancer.
|
Academic Article
|
Immune Escape Strategies in Head and Neck Cancer: Evade, Resist, Inhibit, Recruit.
|